Fig. 3. Abnormal synaptic elimination of NMJ in Gab1-SCKO mice. (A, B) Representative confocal micrographs of polyinnervated endplates in Gab1f/f and Gab1-SCKO mice at P10 (A) and in adults (B, 8W). Arrowheads and arrows indicate polyinnervating and monoinnervating motor nerves, respectively. Asterisk in A indicates polyinnervated endplate. NF, neurofilament. Scale bar=20 µm. (C) Quantitative results of polyinnervation in Gab1f/f and Gab1-SCKO mice (n=3) at P10 and in adulthood (8 weeks). (D, E) Quantitative results showing the numbers of AChR islands (D) and the areas (E) of NMJs in Gab1f/f and Gab1-SCKO mice (n=3). (F) Quantitative analysis of endplate maturation in Gab1f/f and Gab1-SCKO mice at P14 (J) (n=3). Data are mean±SEM. *p<0.05, **p<0.01. NS, non-significant.
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