Fig. 1. Ca²⁺-dependent spike frequency adaptation and adaptation index. (A) TC neuron with a depolarizing current injection to induce tonic firing in 2.4 mM Ca²⁺ buffer displays the prolongation of inter-spike intervals (ISI). Adaptation index can be obtained from the ration of 1^st ISI over n^th ISI. (B) Replacement of extracellular buffer to Ca²⁺-free buffer abolishes the spike-frequency adaptation.

Exp Neurobiol 2017;26:179~185 https://doi.org/10.5607/en.2017.26.4.179

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