Fig. 3. Ca2+-dependent spike frequency adaptation mediated by Ca2+-activated chloride channels in TC and CA1 neurons. When a neuron is highly activated, Ca2+influx via voltage gated Ca2+ channel would increase the local [Ca2+]in in turn activate ANO2. The influx of Cl- caused by the low [Cl-]in in CNS neurons would hyperpolarize membrane potential, which would decrease the spike generation probability.
© Exp Neurobiol
