Fig. 1. After primary astrocyte culture, major gliotransmitters in media from wild type (WT) or GIT1 Knock Out (GIT1 KO) mice are analyzed by HPLC. Bar graph shows concentration of excitatory transmitter, glutamate (left); inhibitory transmitter, GABA (middle); and excitatory/inhibitory ratio (right). GIT1 KO mice show lower GABA concentration and higher E/I ratios (Glutamate p=0.8, GABA p=0.60, E/I ratio p=0.68, analyzed by unpaired t test, n=22; from 15 mice of WT and 7 mice of KO).
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