Fig. 3. (A) Representative traces of whole cell patch clamp recordings from granule cells in cerebellar slices in WT (Left) and GIT1 KO (Right). 5 µM of GABA is treated on the slices for the full activation of the all GABA receptors. The tonic current was measured as a blocked current by 10 µM GABAzine treatment (black arrow). The measurements are summarized in (B). Tonic current is significantly decreased in KO mice. The full activation current with 5µM of GABA is not different between WT and KO (n=18; from 4 mice of WT and 5 mice of KO, *p<0.05, **p<0.01).
© Exp Neurobiol
