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Fig. 2EComparable schematic diagram of cerebellar cortex in WT and GIT1 KO mice. Reduced GABA in the astrocytes was observed in GIT1 KO compared to WT (). This reduced astrocytic GABA induced less tonic GABA less tonic currents mediated by tonic GABA release via Best1 channels. Conclusively, attenuation of tonic inhibition make increase of E/I balance and can explain hyperactivity for ADHD. BG, Bergmann glia; GC, Granule cell; LA, Lamellar astrocyte; PF, Parallel fiber.
Exp Neurobiol 2017;26:206~212
© Exp Neurobiol