Fig. 2EComparable schematic diagram of cerebellar cortex in WT and GIT1 KO mice. Reduced GABA in the astrocytes was observed in GIT1 KO compared to WT (
). This reduced astrocytic GABA induced less tonic GABA less tonic currents mediated by tonic GABA release via Best1 channels. Conclusively, attenuation of tonic inhibition make increase of E/I balance and can explain hyperactivity for ADHD. BG, Bergmann glia; GC, Granule cell; LA, Lamellar astrocyte; PF, Parallel fiber.
