Fig. 1. Experimental scheme and the antiseizure effects of silibinin on KA-treated mice. (A) Experimental scheme detailing silibinin administration. (B) Mice received twice intraperitoneal injections of silibinin (50, 100, 200 mg/kg) 1 day and 1 hour before KA treatment, and then they were treated with intrahippocampal injection of KA to induce seizures. Treatment with silibinin significantly increased latency of seizure onset in mice compared with KA alone. *p<0.01 vs. KA alone (one-way ANOVA and Tukey's post-hoc analysis; n=4, each experimental group). All values are expressed as the mean±standard error of the mean (SEM). (C) The frequency of SRS was evaluated for 2 weeks starting 3 weeks after KA treatment. Treatment with 200 mg/kg silibinin for 5 weeks showed significant decrease in the frequency of SRS compared to KA alone *p<0.05 vs. KA alone (t-test analysis; n=6, each experimental group). All values are expressed as the mean±standard error of the mean (SEM).
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