Fig. 3. Neuroprotective effects of silibinin against KA-induced excitotoxicity. (A) Silibinin was intraperitoneally injected for 8 days, starting 1 day before KA treatment, and NeuN immunostaining of representative coronal sections are performed 7 days after KA treatment. Scale bar, 500 µm and 50 µm, respectively. (B) The histogram quantitatively shows the percentage of NeuN-positive neurons in the counting area of the hippocampal CA1 region compared with the contralateral controls. *p<0.01 vs. PBS alone, #p<0.05 vs. KA alone (one-way ANOVA and Tukey's post-hoc analysis; n=4, each experimental group). All values are expressed as the mean±standard error of the mean (SEM).
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