Fig. 2. Inhibition of PDK with DCA induced cell death of GBMs under normoxia, but not under hypoxia. (A~D) Cell viability levels of GBMs (U251, GBM28 and GBM37) and NSC10 in response to different doses (5, 10, or 20 mM) of DCA or vehicle under normoxia (20% O2) and hypoxia (1% O2). Cells were treated with indicated doses of DCA for 48 hours. Cell viability levels were measured with the MTT assay. (E~G) Assessments of the mitochondrial complex I (E), II (F), and IV (G) activities in different GBM cells maintained under normoxia (20% O2). Data are presented as the means±S.E.M (n≥6). *, **, and *** denote difference between control and indicated point at p<0.05, p<0.01, and p<0.001, respectively. #, ##, and ### denote difference between normoxic and hypoxic groups at p<0.05, p<0.01, and p<0.001, respectively (Student's t test, one-way ANOVA followed by post hoc test).
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