Fig. 4. Co-treatment with chrysin and DCA additively induced cell death of GBMs. (A~D) Cell viability levels of GBMs and NSC10 treated with a combination of chrysin (10 µM) and DCA (10 or 20 mM) under normoxia (20% O2) and hypoxia (1% O2). Cells were treated with indicated doses of chrysin and DCA for 48 hours. Cell viability levels were measured with the MTT assay. (E~H) Cell viability levels of GBMs and NSC10 treated with a combination of chrysin (100 µM) and DCA (10 or 20 mM) under normoxia (20% O2) and hypoxia (1% O2). Cells were treated as above. Data are presented as the means±S.E.M (n=6). *, **, and *** denote difference between control and indicated point at p<0.05, p<0.01, and p<0.001, respectively. #, ##, and ### denote difference between normoxic and hypoxic groups at p<0.05, p<0.01, and p<0.001, respectively (One-way ANOVA followed by post hoc test).
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