Fig. 1. The diversity and percent composition of microbiota at the phylum level in control vs. ASD subjects. (A) Rarefication curves representing the mean OTUs over the identified sequences of variable regions of 16S rRNA gene in control (blue) and ASD (red) subjects. Data are the mean +/− SEM (n=5, each). (B) Principal component analysis of microbiota diversity based on the weighted UniFrac distance and Bray-Curtis dissimilarity. Data were normalized to have a mean of 0 and a standard deviation of 1. Control (blue) and ASD (red). (C) Overall composition of microbiota at the phylum level in control (blue) and ASD (red) subjects. Those with occupancy 0.1% or higher in control and/or ASD subjects are presented. (D) The percent composition of microbiota at the phylum level in control and ASD subjects. ↑ and ↓ denote an increase and decrease in the percent composition, respectively. Data are the mean +/− SEM (n=5, each). * and ** denote the differences between the indicated groups at p<0.05 and p<0.01, respectively (Student's t-test).
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