Experimental Neurobiology

Table 2The percent composition of microbiota at the class, order, and family taxonomic levels in control and ASD subjects

Class					Order					Family
Taxon	Mean (%)		Fold change	p-value	Taxon	Mean (%)		Fold change	p-value	Taxon	Mean (%)		Fold change	p-value
Taxon	Control	ASD	Fold change	p-value	Taxon	Control	ASD	Fold change	p-value	Taxon	Control	ASD	Fold change	p-value
Gammaproteobacteria	23.51	23.47	1	0.99	Oceanospirillales	0.21	2.62	12.68	0.02^*	Halomonadaceae	0.2	2.61	↑ 13.16	0.02^*
Alphaproteobacteria	15.29	4.84	0.32	0^**	Sphingomonadales	6.29	1.98	0.31	0^**	Sphingomonadaceae	6.27	1.98	↓ 0.32	0^**
					Rhizobiales	5.69	1.05	0.19	0^**	Rhizobiaceae	4.58	0.18	↓ 0.04	0^**
										Bradyrhizobiaceae	0.46	0.08	↓ 0.17	0.01^*
					Rickettsiales	0.94	0.1	0.11	0.04^*	mitochondria	0.84	0.1	↓ 0.12	0.02^**
Betaproteobacteria	10.09	6.26	0.62	0.1	Burkholderiales	9.5	5.73	0.6	0.11	Comamonadaceae	2.55	4.37	↑ 1.71	0.01^*
										Alcaligenaceae	2.53	0.12	↓ 0.05	0^**
Deltaproteobacteria	0.2	0.64	3.23	0.01^*	Desulfovibrionales	0.06	0.53	9.66	0^**	Desulfovibrionaceae	0.06	0.53	↑ 9.66	0^**
Bacilli	12.84	17.55	1.37	0.07	Lactobacillales	7.92	11.94	1.51	0.07	Streptococcaceae	1.93	4.88	↑ 2.52	0.04^*
Clostridia	11.63	15.4	1.32	0.18	Clostridiales	11.59	15.38	1.33	0.18	Unclassified	1.06	1.87	↑ 1.75	0.04^*
										Clostridiaceae	0.44	1.19	↑ 2.70	0.02^*
										Eubacteriaceae	0	0.15	↑ 146.23	0.04^*
Actinobacteria	9.9	11.09	1.12	0.38	Actinomycetales	7.84	10.29	1.31	0.09	Nocardiaceae	0.4	1.56	↑ 3.91	0.02^*
					Bifidobacteriales	2.06	0.8	0.39	0.03^*	Bifidobacteriaceae	2.06	0.8	↓ 0.39	0.03^*
Bacteroidia	5.05	7.28	1.44	0.21	Bacteroidales	5.05	7.28	1.44	0.21	S24-7	0.84	2.02	↑ 2.40	0.04^*
Flavobacteriia	0.56	1.19	2.11	0.03^*	Flavobacteriales	0.56	1.19	2.11	0.03^*	[Weeksellaceae]	0.43	1.12	↑ 2.63	0.01^*
Chloroplast	3.81	1.76	0.46	0.03^*	Streptophyta	3.8	1.68	0.44	0.03^*	Unclassified	3.8	1.68	↓ 0.44	0.03^*
Verrucomicrobiae	0.52	2.35	4.49	0.02^*	Verrucomicrobiales	0.52	2.35	4.49	0.02^*	Verrucomicrobiaceae	0.52	2.35	↑ 4.49	0.02^*
[Fimbriimonadia]	0.38	0	0	0^**	[Fimbriimonadales]	0.38	0	0	0^**	[Fimbriimonadaceae]	0.38	0	↓ 0.00	0^**
Deinococci	0.07	0.47	6.47	0^**	Thermales	0.03	0.21	6.3	0.02^*	Thermaceae	0.03	0.21	↓ 6.30	0.02^*
TM7-3	0.05	0.37	6.96	0.05^*

Microbiota at the family level whose occupancy was significantly different in ASD subjects are presented with associated higher taxonomy levels. Those occupying 0.1% or higher in either normal healthy or ASD subjects were included. ↑ and ↓ denote an increase and decrease in the percent composition, respectively. Data are the mean percentages. * and ** denote significant differences between the indicated groups at p<0.05 and p<0.01, respectively (Student's t-test).

Exp Neurobiol 2017;26:307~317 https://doi.org/10.5607/en.2017.26.5.307