Experimental Neurobiology

Table 3The percent composition of microbiota at the genus level in control and ASD subjects

Class	Order	Family	Taxon	Mean±SEM (%)		Fold change	p-value
Class	Order	Family	Taxon	Control	ASD	Fold change	p-value
Gammaproteobacteria	Oceanospirillales	Halomonadaceae	Halomonas	0.12±0.06	1.72±0.51	↑ 14.61	0.01^*
	Pseudomonadales	Pseudomonadaceae	Pseudomonas	7.48±0.86	5.10±0.6	↓ 0.68	0.03^*
	Enterobacteriales	Enterobacteriaceae	Erwinia	0.26±0.1	0.64±0.15	↑ 2.41	0.04^*
			Citrobacter	0.66±0.24	0.08±0.05	↓ 0.12	0.02^*
			Unclassified	8.85±1.01	6.08±0.58	↓ 0.69	0.02^*
Alphaproteobacteria	Sphingomonadales	Sphingomonadaceae	Sphingomonas	4.17±0.83	0.71±0.2	↓ 0.17	0.00^**
	Rhizobiales	Rhizobiaceae	Agrobacterium	3.83±0.96	0.11±0.05	↓ 0.03	0.00^**
			Unclassified 1	0.63±0.17	0.07±0.03	↓ 0.11	0.00^**
			Unclassified 2	0.11±0.03	0.00±0.00	↓ 0.00	0.00^*
		Bradyrhizobiaceae	Unclassified	0.24±0.07	0.05±0.02	↓ 0.21	0.02^*
	Rickettsiales	Mitochondria	Unclassified	0.84±0.3	0.1±0.06	↓ 0.12	0.02^*
Betaproteobacteria	Rhodobacterales	Rhodobacteraceae	Rhodobacter	0.01±0.01	0.23±0.08	↑ 20.34	0.02^*
	Burkholderiales	Comamonadaceae	Roseateles	1.12±0.35	0.02±0.01	↓ 0.02	0.00^**
			Delftia	0.22±0.08	0.01±0.00	↓ 0.05	0.02^*
			Comamonas	0.08±0.05	0.36±0.12	↑ 4.48	0.04^*
			Unclassified	0.92±0.15	3.79±0.49	↑ 4.14	0.00^**
		Alcaligenaceae	Achromobacter	2.42±0.75	0.05±0.03	↓ 0.02	0.00^**
Deltaproteobacteria	Desulfovibrionales	Desulfovibrionaceae	Desulfovibrio	0.04±0.02	0.48±0.14	↑ 10.88	0.00^*
Bacilli	Lactobacillales	Streptococcaceae	Streptococcus	1.58±0.26	4.77±1.28	↑ 3.03	0.02^*
Bacilli	Bacillales	Staphylococcaceae	Jeotgalicoccus	0.03±0.02	0.50±0.11	↑ 14.70	0.00^*
Clostridia	Clostridiales	Unclassified	Unclassified	1.06±0.26	1.87±0.26	↑ 1.75	0.04^*
		Clostridiaceae	Unclassified	0.27±0.08	0.70±0.18	↑ 2.58	0.04^*
		Ruminococcaceae	Oscillospira	0.10±0.04	0.47±0.14	↑ 4.53	0.02^*
Actinobacteria	Actinomycetales	Nocardiaceae	Rhodococcus	0.40±0.13	1.56±0.43	↑ 3.91	0.02^*
Actinobacteria	Actinomycetales	Micrococcaceae	Kocuria	0.06±0.05	0.30±0.08	↑ 4.75	0.01^*
Bacteroidia	Bacteroidales	S24-7	Unclassified	0.84±0.36	2.02±0.44	↑ 2.40	0.04^*
Flavobacteriia	Flavobacteriales	[Weeksellaceae	Cloacibacterium	0.13±0.06	0.62±0.2	↑ 4.92	0.03^*
Chloroplast	Streptophyta	Unclassified	Unclassified	3.80±0.84	1.68±0.38	↓ 0.44	0.03^*
Verrucomicrobiae	Verrucomicrobiales	Verrucomicrobiaceae	Akkermansia	0.52±0.18	2.35±0.68	↑ 4.52	0.02^*
[Fimbriimonadia]	[Fimbriimonadales]	[Fimbriimonadaceae]	Fimbriimonas	0.38±0.12	0.00±0.00	↓ 0.00	0.00^**
Deinococci	Thermales	Thermaceae	Thermus	0.03±0.02	0.21±0.07	↑ 6.30	0.02^*

Microbiota at the genus level whose occupancy was significantly different in ASD subjects are presented with associated higher taxonomy levels. Microbiota with occupancy 0.1% or higher in either normal healthy or ASD subjects were considered. ↑ and ↓ denote an increase and decrease in the percent composition, respectively.

Data are the mean percentage±SEM. * and ** denote significant differences between the indicated groups at p<0.05 and p<0.01, respectively (Student's t-test).

Exp Neurobiol 2017;26:307~317 https://doi.org/10.5607/en.2017.26.5.307