Experimental Neurobiology

Table 1The percent compositions of microbiomes at the levels of class, order, and family in wild-type and Tg-APP/PS1 mice

Phylum				Clas				Order				Family
Taxon	Occupancy (%; Mean)		z-score	Taxon	Occupancy (%; Mean)		z-score	Taxon	Occupancy (%; Mean)		z-score	Taxon	Occupancy (%; Mean)		z-score
Taxon	WT	Tg	z-score	Taxon	WT	Tg	z-score	Taxon	WT	Tg	z-score	Taxon	WT	Tg	z-score
Firmicutes	34.7	57.5	↑ 3.4	Clostridia	18.1	25.9	↑ 1.4	Clostridiales	18.1	25.9	↑ 1.4	^*Unidentified	4.7	7	↑ 1.1
												Lachnospiraceae	3.1	5.9	↑ 1.5
												[Mogibacteriaceae]	0	0.1	↑ <<
												Eubacteriaceae	0	0.1	↑ <<
				Bacilli	16	30.3	↑ 5.4	Lactobacillales	8.3	17	↑ 3.2	Lactobacillaceae	5.7	3.1	↓ −1.7
												Aerococcaceae	0.6	11.1	↑ 10.6
												Leuconostocaceae	0	0.3	↑ 4.2
								Bacillales	7.3	12.9	↑ 1.1	Staphylococcaceae	6.4	12	↑ 1
								Other	0	0.3	↑ 27.8	Other	0	0.3	↑ 27.8
Proteobacteria	30.5	20.7	↓ −1.6	Gammaproteobacteria	14.4	13		Pseudomonadales	9.1	8.8		Pseudomonadaceae	3.1	4.5	↑ 1.4
				Gammaproteobacteria	14.4	13		Xanthomonadales	0	0.1	↑ 5.6	Xanthomonadaceae	0	0.1	↑ 5.6
				Alphaproteobacteria	10.2	3.7		Sphingomonadales	3.8	0.7	↓ −1.1	Sphingomonadaceae	3.8	0.7	↓ −1.1
								Rhizobiales	1	1.4		Bartonellaceae	0	0.1	↑ <<
								Caulobacterales	0.2	0.9	↑ 2.1	Caulobacteraceae	0.2	0.9	↑ 2.1
				Betaproteobacteria	4.7	3.4		Burkholderiales	4.2	3.2		Comamonadaceae	2.5	1.1	↓ −1.1
				Betaproteobacteria	4.7	3.4		Rhodocyclales	0.2	0	↓ >>	Rhodocyclaceae	0.2	0	↓ >>
Bacteroidetes	17.8	8.7		Bacteroidia	17.5	7.9		Bacteroidales	17.5	7.9		S24-7	6.3	1.8	↓ −1
				Bacteroidia	17.5	7.9		Bacteroidales	17.5	7.9		[Odoribacteraceae]	0	0.1	↑ <<
				Flavobacteriia	0.3	0.3		Flavobacteriales	0.3	0.3		Flavobacteriaceae	0.2	0	↓ >>
				Cytophagia	0	0.2	↑ <<	Cytophagales	0	0.2	↑ <<	Cytophagaceae	0	0.2	↑ <<
				Sphingobacteriia	0	0.2	↑ 2.6	Sphingobacteriales	0	0.2	↑ 2.6	Sphingobacteriaceae	0	0.2	↑ 2.6
Actinobacteria	7.7	5.2		Actinobacteria	6.9	4.3		Actinomycetales	6.1	3.3		Corynebacteriaceae	3.5	0.9	↓ −1.4
												Micrococcaceae	0	0.1	↑ <<
												Nocardioidaceae	0	0.1	↑ 6.2
TM7	3.8	2.6		TM7-3	3.8	2.6		^*Unidentified	0	0.2	↑ <<	^*Unidentified	0	0.2	↑ <<
Tenericutes	0.9	0.3	↓ −1.1	Mollicutes	0.9	0.3	↓ −1.1	RF39	0.9	0.3	↓ −1.1	^*Unidentified	0.9	0.3	↓ −1.1
Cyanobacteria	0.9	0.5		4C0d-2	0	0.2	↑ 1.4	YS2	0	0.2	↑ 1.4	^*Unidentified	0	0.2	↑ 1.4
Gemmatimonadetes	0.2	0		Gemmatimonadetes	0.2	0	↓ >>	Gemmatimonadales	0.1	0	↓ >>	^*Unidentified	0.1	0	↓ >>
Gemmatimonadetes	0.2	0		Gemmatimonadetes	0.2	0	↓ >>	^*Unidentified	0.1	0	↓ >>	^*Unidentified	0.1	0	↓ >>
[Thermi]	0	0.2	↑ <<	Deinococci	0	0.2	↑ <<	Deinococcales	0	0.2	↑ <<	Deinococcaceae	0	0.2	↑ <<
Fibrobacteres	0	0.1	↑ <<	TG3	0	0.1	↑ <<	TG3-1	0	0.1	↑ <<	TSCOR003-O20	0	0.1	↑ <<
Summation	96.5	95.6			93.1	92.6			77.3	83.9			41.5	51.8

The family members of microbiomes for which occupancy differed by more than one standard deviation (SD; one z) in Tg-APP/PS1 mice from that of wild-type mice are presented, along with the higher taxonomy levels. Those occupying 0.1% and higher in either wild-type or Tg-APP/PS1 mice were included.

Data are presented as the mean percentages and z-scores. The z-score is X − µ/σ, where µ=mean; X=individual score; σ=standard deviation (SD). Increases and decreases in the mean occupancy by more than one z in Tg-APP/PS1 are indicated by ↑ and ↓, respectively. « and » denote infinite increases and decreases, respectively.

¹⁾APPswe/PSEN1dE9; ²⁾APPswe/PSEN1-L166P

Exp Neurobiol 2017;26:369~379 https://doi.org/10.5607/en.2017.26.6.369