The percent compositions of microbiomes at the genus level in wild-type and Tg-APP/PS1 mice
TaxonOccupancy (%; Mean±SEM)Fold changez-score
WTTg-APP/PS
p__Bacteroidetes;c__Bacteroidia;o__Bacteroidales;f__S24-7;g__6.3±1.971.81±0.53↓ −3.5−1
p__Firmicutes;c__Bacilli;o__Lactobacillales;f__Lactobacillaceae;g__Lactobacillus5.57±0.583.13±0.85↓ −1.8−1.9
p__Firmicutes;c__Clostridia;o__Clostridiales;f__;g__4.66±17.03±2.78↑ 1.51.1
p__Actinobacteria;c__Actinobacteria;o__Actinomycetales;f__Corynebacteriaceae;g__Corynebacterium3.5±0.790.94±0.39↓ −3.7−1.4
p__Proteobacteria;c__Gammaproteobacteria;o__Pseudomonadales;f__Pseudomonadaceae;g__Pseudomonas2.78±0.384.13±0.87↑ 1.51.6
p__Firmicutes;c__Clostridia;o__Clostridiales;f__Ruminococcaceae;g__2.44±0.656.09±2.2↑ 2.52.5
p__Tenericutes;c__Mollicutes;o__RF39;f__;g__0.92±0.260.26±0.15↓ −3.6−1.1
p__Firmicutes;c__Bacilli;o__Bacillales;f__Staphylococcaceae;g__Jeotgalicoccus0.83±0.628.5±5.49↑ 10.25.5
p__Proteobacteria;c__Alphaproteobacteria;o__Rhodobacterales;f__Rhodobacteraceae;g__Amaricoccus0.41±0.410±0↓ >>>>
p__Proteobacteria;c__Betaproteobacteria;o__Burkholderiales;f__Oxalobacteraceae;g__Ralstonia0.21±0.160±0↓ >>>>
p__Firmicutes;c__Erysipelotrichi;o__Erysipelotrichales;f__Erysipelotrichaceae;g__0.19±0.080.47±0.19↑ 2.51.5
p__Fusobacteria;c__Fusobacteriia;o__Fusobacteriales;f__Leptotrichiaceae;g__Leptotrichia0.18±0.110±0↓ >>>>
p__Bacteroidetes;c__Flavobacteriia;o__Flavobacteriales;f__Flavobacteriaceae;g__Flavobacterium0.16±0.160±0↓ >>>>
p__Proteobacteria;c__Betaproteobacteria;o__Burkholderiales;f__Alcaligenaceae;g__Oligella0.15±0.150±0↓ >>>>
p__Firmicutes;c__Clostridia;o__Clostridiales;f__Lachnospiraceae;g__Lachnospira0.15±0.10±0↓ >>>>
p__Firmicutes;c__Bacilli;o__Bacillales;f__Planococcaceae;g__Sporosarcina0.14±0.140.49±0.49↑ 3.61.2
p__Actinobacteria;c__Actinobacteria;o__Bifidobacteriales;f__Bifidobacteriaceae;g__0.14±0.080±0↓ >>>>
p__Proteobacteria;c__Betaproteobacteria;o__Rhodocyclales;f__Rhodocyclaceae;g__Methyloversatilis0.13±0.130±0↓ >>>>
p__Proteobacteria;c__Alphaproteobacteria;o__Sphingomonadales;f__Sphingomonadaceae;g__Sphingopyxis0.13±0.080±0↓ >>>>
p__Firmicutes;c__Bacilli;o__Lactobacillales;f__Aerococcaceae;g__Alloiococcus0.13±0.090±0↓ >>>>
p__Firmicutes;c__Clostridia;o__Clostridiales;f__Lachnospiraceae;g__Blautia0.12±0.111.37±0.95↑ 11.15.3
p__Gemmatimonadetes;c__Gemmatimonadetes;o__;f__;g__0.11±0.110±0↓ >>>>
p__Gemmatimonadetes;c__Gemmatimonadetes;o__Gemmatimonadales;f__;g__0.11±0.110±0↓ >>>>
p__Proteobacteria;c__Betaproteobacteria;o__Burkholderiales;f__Oxalobacteraceae;g__0.08±0.050.28±0.21↑ 3.41.6
p__Proteobacteria;c__Alphaproteobacteria;o__Rhizobiales;f__Methylobacteriaceae;g__0.06±0.050.34±0.2↑ 5.82.3
p__Bacteroidetes;c__Bacteroidia;o__Bacteroidales;f__Porphyromonadaceae;g__Parabacteroides0.06±0.060.28±0.19↑ 51.8
p__Cyanobacteria;c__4C0d-2;o__YS2;f__;g__0.05±0.050.19±0.12↑ 41.4
p__Firmicutes;c__Clostridia;o__Clostridiales;f__Lachnospiraceae;Other0.04±0.030.45±0.41↑ 10.16.9
p__Proteobacteria;c__Alphaproteobacteria;o__Caulobacterales;f__Caulobacteraceae;g__0.04±0.010.81±0.51↑ 18.729.6
p__Proteobacteria;c__Gammaproteobacteria;o__Enterobacteriales;f__Enterobacteriaceae;Other0.04±0.020.42±0.19↑ 10.47.7
p__Proteobacteria;c__Betaproteobacteria;o__Neisseriales;f__Neisseriaceae;g__Neisseria0.03±0.030.2±0.14↑ 72.7
p__Proteobacteria;c__Gammaproteobacteria;o__Pasteurellales;f__Pasteurellaceae;g__Haemophilus0.02±0.020.14±0.1↑ 6.22.3
p__Firmicutes;c__Bacilli;o__Lactobacillales;f__Aerococcaceae;g__Aerococcus0.02±0.0110.45±8.55↑ 630434.2
p__Actinobacteria;c__Actinobacteria;o__Actinomycetales;f__Nocardioidaceae;g__0.01±0.010.11±0.07↑ 156.2
p__Firmicutes;c__Bacilli;Other;Other;Other0.01±0.010.32±0.3↑ 48.627.8
p__Firmicutes;c__Clostridia;o__Clostridiales;f__Ruminococcaceae;Other0.01±00.24±0.23↑ 40.123.4
p__Firmicutes;c__Bacilli;o__Bacillales;f__Bacillaceae;g__Bacillus0±00.27±0.16↑ 72.432
p__Firmicutes;c__Bacilli;o__Lactobacillales;f__Leuconostocaceae;g__Weissella0±00.18±0.18↑ 149.866.6
p__Firmicutes;c__Clostridia;o__Clostridiales;f__[Mogibacteriaceae];g__0±00.1±0.06↑ <<<<
p__Fibrobacteres;c__TG3;o__TG3-1;f__TSCOR003-O20;g__0±00.11±0.11↑ <<<<
p__Bacteroidetes;c__Bacteroidia;o__Bacteroidales;f__[Odoribacteraceae];g__Odoribacter0±00.11±0.08↑ <<<<
p__Proteobacteria;c__Deltaproteobacteria;o__Desulfovibrionales;f__Desulfovibrionaceae;g__0±00.11±0.1↑ <<<<
p__Bacteroidetes;c__Cytophagia;o__Cytophagales;f__Cytophagaceae;g__Hymenobacter0±00.12±0.12↑ <<<<
p__Firmicutes;c__Clostridia;o__Clostridiales;f__Veillonellaceae;g__Megamonas0±00.13±0.12↑ <<<<
p__Firmicutes;c__Bacilli;o__Lactobacillales;f__Leuconostocaceae;g__0±00.13±0.06↑ <<<<
p__Firmicutes;c__Clostridia;o__Clostridiales;f__Eubacteriaceae;g__Anaerofustis0±00.13±0.1↑ <<<<
p__Bacteroidetes;c__Sphingobacteriia;o__Sphingobacteriales;f__Sphingobacteriaceae;g__0±00.14±0.14↑ <<<<
p__Actinobacteria;c__Actinobacteria;o__Actinomycetales;f__Micrococcaceae;g__Kocuria0±00.14±0.08↑ <<<<
p__Proteobacteria;c__Alphaproteobacteria;o__Rhizobiales;f__Bartonellaceae;g__0±00.14±0.1↑ <<<<
p__TM7;c__TM7-3;o__;f__;g__0±00.16±0.11↑ <<<<
p__[Thermi];c__Deinococci;o__Deinococcales;f__Deinococcaceae;g__Deinococcus0±00.19±0.19↑ <<<<
p__Bacteroidetes;c__Flavobacteriia;o__Flavobacteriales;f__[Weeksellaceae];g__Cloacibacterium0±00.2±0.2↑ <<<<
p__Actinobacteria;c__Coriobacteriia;o__Coriobacteriales;f__Coriobacteriaceae;g__Collinsella0±00.35±0.17↑ <<<<
p__Firmicutes;c__Clostridia;o__Clostridiales;f__Veillonellaceae;g__Veillonella0±00.37±0.27↑ <<<<
p__Firmicutes;c__Bacilli;o__Lactobacillales;f__Streptococcaceae;g__Lactococcus0±00.67±0.62↑ <<<<
Summation29.952.2

The percent compositions of microbiomes at the genus level for which occupancy differed by more than one SD (one z) in Tg-APP/PS1 mice. Microbiomes with occupancies higher than 0.1% in either wild-type or Tg-APP/PS1 mice were included.

Data are presented as the mean percentage +/− SEM. The z-score is X − µ/σ, where µ=mean; X=individual score; σ=standard deviation (SD). The increase and decrease of the mean occupancy by more than one z in Tg-APP/PS1 are indicated by ↑ and ↓, respectively. « and » denote infinite increases and decreases, respectively.

Exp Neurobiol 2017;26:369~379 https://doi.org/10.5607/en.2017.26.6.369
© Exp Neurobiol