Fig. 2. MS and MSEW mice show changes in locomotor activity in the open field during the dark phase but did not display anxiety-like behavior compared to controls. In the open field conducted during the light phase, there were no significant differences on distance traveled over time between (A) MS and MC group and (C) MSEW and MC group. On the time spent in the center zone, which can be interpreted as an anxiety-related behavior, there were no significant differences between (B) MS and MC group and (D) MSEW and MC group. Two mice from the MC group in the MSEW cohort were excluded for severe injuries. In the open field conducted during the dark phase (E) MS mice traveled significantly more than controls during the 30, 35, 40 and 60 min (p<0.01) and (G) MSEW traveled significantly less over time compared to MC (p<0.05), but post-hoc tests were not significant. There were no differences in the time spent in center of the open field between (F) MS and MC and (H) MSEW and MC mice during the dark phase. One mouse from the MC group in the MS cohort was excluded for as an outlier for excessive hyperactivity and one mouse from the MC group in the MSEW cohort was excluded for severe injuries. In the light/dark box test, there were no significant differences in the time spent in light and dark compartments as well as the number of transitions between both compartments between (I and K) MS and MC mice and (J and L) MSEW and MC mice. *Indicates p<0.01 for the post-hoc test for that particular time bin. All values are means±SEM.
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