Summary of some commonly used maternal separation paradigms and behavioral effects in adult male mice on emotion-related behaviors
StrainsMaternal separation paradigmBehavioral phenotype in MS group in adulthood (compared to controls)Reference
C57BL/6J3 hours MS on P1–P9Elevated anxiety-like behavior in EPM and OF.[14]
CD-13 hours MS on P2–P14Decreased anxiety-like behavior in EPM.[15]
CD-124 hour MS on P12No changes in locomotor activity in OF. No change in total time spent immobile in FST.[16]
C57BLl/6NCrlBR3 hours MS on P0–P9No changes in anxiety-related behavior in DWT.[17]
C57BL/6J3 hours MS on P1–P10No change in DWT. Decreased anxiety-like behavior in dark phase EZM but increased anxiety in EPM.[18]
129S1, BALB/cByJ, C57BL/6J, DBA/2J, FVB/NJ3 hours MS on P0–13No overall changes in anxiety and depressive-related behavior in EPM, LDB, OF and FST.[10]
C57BL/6J24 hours MS on P9No change in OF activity. Decreased anxiety in EPM.[19]
C57BL/6J3 hour MS on P1–14Increased anxiety in EPM but no change in anxiety behavior in OF.[20]
C57BL/6J and BALB/c3 hours MS on P1–14No change in depressive-like behavior in FST.[21]
C57BL/6J and DBA/2J24 hour MS on P9Lowered anxiety-related behavior in OF. No changes in hole board exploratory activity. No change in depressive-like behavior in FST.[22]
C57BL/6J3 hours MS on P2–14No change in LDB anxiety-related behavior. NSF behavior not affected. Decreased anxiety-like behavior in OF in last 15 minutes. No change in depressive-like behavior in FST.[23]
CCR7 deficient C57BL/6J3 hours MS on P1–14No change in anxiety-like behavior in OF and EZM. No change in depressive-like behavior in saccharin preference test.[24]

MS, maternal separation; EPM, Elevated Plus Maze; EZM, Elevated Zero Maze; FST, Forced Swim Test; OF, Open field; DWT, Defensive withdrawal test; LDB, Light/dark box; NSF, Novelty suppressed feeding.

Exp Neurobiol 2017;26:390~398
© Exp Neurobiol