| Bias | Item Number | Question | Li [21] | Liu [22] | Wang [23] | Li [24] | Du et al. [25] | Li et al. [26] | Li et al. [27] | Liu et al. [28] | Liu et al. [29] | Du et al. [30] |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Randomization | 1 | Were animals randomized across groups? | Y | Y | Y | Y | Y | Y | Y | Y | Y | Y |
| 2 | What method was used for randomization? | Y | U | U | U | U | Y | Y | U | U | U | |
| Blindness | 3 | Was the outcome assessment blinded? | U | U | U | U | U | U | U | U | U | U |
| Experimental animals | 4 | Were characteristics of experimental animals clearly described? | Y | Y | Y | Y | Y | Y | Y | Y | Y | Y |
| Baseline | 5 | Were the groups similar at baseline? | Y | Y | Y | Y | U | Y | Y | Y | Y | Y |
| Homogeneity | 6 | Was each treatment homogeneous? | Y | Y | Y | Y | Y | Y | Y | Y | Y | Y |
| 7 | Was the method of outcome measurement proper and homogeneous? | Y | Y | Y | Y | Y | Y | Y | Y | Y | Y | |
| Data completion | 8 | Was the number of animals excluded from analysis and the reason for exclusion clear? | U | U | U | U | U | U | U | U | U | U |
| 9 | Were the outcome data complete? | Y | Y | N | Y | Y | Y | Y | Y | Y | Y |
Y, yes; N, no description; U, unclear description.