| Study | Animal model | Treatment | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Species | Age (month) | Weight (g) | Sample size | Induced disease | Acupoint | Moxibustion diameter (mm) | Duration (min) | Treatment method and period | |||
| Moxa (M,F) | Control (M,F) | Before inducing model | After inducing model | ||||||||
| Li [21] | SD rat | 15 | 350~480 | (100) | (100) | AD | GV20, BL23, ST36 | 8 | 5 | 18 times for 21 days | (After 1 day) 6 times for 7 days |
| Liu [22] | SD rat | 12±2 | 360±20 | (100) | (100) | AD | GV20, BL23 | 15~20 | 10 | 40 times for 56 days | (After 4 day) 11 timesfor 11 days |
| Wang [23] | SD rat | 12 | 400±50 | (100) | (100) | AD | GV20, BL23 | NR | 10 | 40 times for 56 days | |
| Li [24] | SD rat | 12±2 | 360±20 | (55) | (55) | AD | GV20, BL23 | NR | 5 | 40 times for 56 days | |
| Du et al. [25] | Wistar rat | 12 | 500±20 | (100) | (100) | AD | GV20, BL23 | 6 | 15 | 48 times for 56 days | 14 times for 14 days |
| Li et al. [26] | SD rat | 15 | 350~480 | (100) | (100) | AD | GV20, BL23, ST36 | 8 | 5 | 18 times for 21 days | (After 1 day) 6 times for 7 days |
| Li et al. [27] | SD rat | 15 | 350~480 | (100) | (100) | AD | GV20, BL23, ST36 | 8 | 5 | 18 times for 21 days | (After 1 day) 6 times for 7 days |
| Liu et al. [28] | SD rat | 12±2 | 360±20 | (55) | (55) | AD | GV20, BL23 | 6 | 10 | 18 times for 21 days | 7 times for 7 days |
| Liu et al. [29] | SD rat | 12±2 | 360±20 | (55) | (55) | AD | GV20, BL23 | NA | 5 | 40 times for 56 days | |
| Du et al. [30] | SD rat | 10±2 | 360±20 | (55) | (55) | AD | GV20, BL23 | 6 | 10 | 18 times for 21 days | 7 times for 7 days |
| Study | Outcome | |||||
|---|---|---|---|---|---|---|
| Behavior test morris water maze | Signal pathway | |||||
| Li [21] | 1. Escape latency | P-p38MAPK ↓, | ||||
| 2. Crossing times | COX-2 ↓, | |||||
| 3. Dwelling time | PGE2 ↓ | |||||
| Liu [22] | 1. Escape latency | 14-3-3 protein ↑, | ||||
| 2. Crossing times | Apoptosis rates ↓ | |||||
| 3. Dwelling time | ||||||
| Wang [23] | 1. Escape latency | NGF ↑, | ||||
| 2. Crossing times | BDNF ↑ | |||||
| Li [24] | 1. Escape latency | CDK5 ↓, | ||||
| 2. Crossing times | p27kip1 ↑ | |||||
| 3. Dwelling time | ||||||
| Du et al. [25] | 1. Escape latency | Apoptosis rates ↓ | ||||
| 2. Crossing times | ||||||
| 3. Dwelling time | ||||||
| Li et al. [26] | None | BDNF ↑, | ||||
| TrkB ↑ | ||||||
| Li et al. [27] | None | NGF ↑, | ||||
| TrkA ↑ | ||||||
| Liu et al. [28] | None | CylinA ↓, | ||||
| p21 /cip ↑ | ||||||
| Liu et al. [29] | None | CDK2 ↓, | ||||
| p21 /cip ↑ | ||||||
| Du et al. [30] | None | Hsp70 ↑, | ||||
| Hsp90 ↑ | ||||||
SD, Sprague-Dawley; M, male; F, female; Moxa, moxibustion; AD, Alzheimer's disease; NR, not reported; NGF, nerve growth factor; Trk, tropomyosin receptor kinase; BDNF, brain-derived neurotrophic factor; CDK, cyclin-dependent kinase; PGE, prostaglandin E; COX, cyclooxygenase; P-p38 MAPK, phospho-p38 mitogen-activated protein kinase.