Assessment of methodological quality in the included studies
StudyAnimal modelTreatment
SpeciesAge (month)Weight (g)Sample sizeInduced diseaseAcupointMoxibustion diameter (mm)Duration (min)Treatment method and period
Moxa (M,F)Control (M,F)Before inducing modelAfter inducing model
Li [21]SD rat15350~480(100)(100)ADGV20, BL23, ST368518 times for 21 days(After 1 day) 6 times for 7 days
Liu [22]SD rat12±2360±20(100)(100)ADGV20, BL2315~201040 times for 56 days(After 4 day) 11 timesfor 11 days
Wang [23]SD rat12400±50(100)(100)ADGV20, BL23NR1040 times for 56 days
Li [24]SD rat12±2360±20(55)(55)ADGV20, BL23NR540 times for 56 days
Du et al. [25]Wistar rat12500±20(100)(100)ADGV20, BL2361548 times for 56 days14 times for 14 days
Li et al. [26]SD rat15350~480(100)(100)ADGV20, BL23, ST368518 times for 21 days(After 1 day) 6 times for 7 days
Li et al. [27]SD rat15350~480(100)(100)ADGV20, BL23, ST368518 times for 21 days(After 1 day) 6 times for 7 days
Liu et al. [28]SD rat12±2360±20(55)(55)ADGV20, BL2361018 times for 21 days7 times for 7 days
Liu et al. [29]SD rat12±2360±20(55)(55)ADGV20, BL23NA540 times for 56 days
Du et al. [30]SD rat10±2360±20(55)(55)ADGV20, BL2361018 times for 21 days7 times for 7 days
StudyOutcome
Behavior test morris water mazeSignal pathway
Li [21]1. Escape latencyP-p38MAPK ↓,
2. Crossing timesCOX-2 ↓,
3. Dwelling timePGE2 ↓
Liu [22]1. Escape latency14-3-3 protein ↑,
2. Crossing timesApoptosis rates ↓
3. Dwelling time
Wang [23]1. Escape latencyNGF ↑,
2. Crossing timesBDNF ↑
Li [24]1. Escape latencyCDK5 ↓,
2. Crossing timesp27kip1 ↑
3. Dwelling time
Du et al. [25]1. Escape latencyApoptosis rates ↓
2. Crossing times
3. Dwelling time
Li et al. [26]NoneBDNF ↑,
TrkB ↑
Li et al. [27]NoneNGF ↑,
TrkA ↑
Liu et al. [28]NoneCylinA ↓,
p21 /cip ↑
Liu et al. [29]NoneCDK2 ↓,
p21 /cip ↑
Du et al. [30]NoneHsp70 ↑,
Hsp90 ↑

SD, Sprague-Dawley; M, male; F, female; Moxa, moxibustion; AD, Alzheimer's disease; NR, not reported; NGF, nerve growth factor; Trk, tropomyosin receptor kinase; BDNF, brain-derived neurotrophic factor; CDK, cyclin-dependent kinase; PGE, prostaglandin E; COX, cyclooxygenase; P-p38 MAPK, phospho-p38 mitogen-activated protein kinase.

Exp Neurobiol 2018;27:1~15 https://doi.org/10.5607/en.2018.27.1.1
© Exp Neurobiol