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Fig. 5. A schematic diagram showing that EWSR1 deficiency reduces neuronal nucleus size (atrophy) and, in parallel, causes the reduction of tyrosine hydroxylase in the substantia nigra. Non-phosphorylated DARPP-32 and phosphorylated (p)-DARPP32 (Thr75) are differentially regulated in the striatum of Ewsr1 mice, indicating that the dopaminergic signaling pathway is abnormaly regulated by EWSR1 deficiency. Consequently, EWSR1 deficiency leads to motor behavioral dysfunction in mice.
Exp Neurobiol 2018;27:103~111
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