Experimental Neurobiology

Table 1Active properties of resurgent Na<sup>+</sup> channels in the cerebellar PCs and their physiological and pathological roles

Na_V1.6 (Resurgent Na⁺ channel)
Expression	Dendrite, Node of ranvier	[51]
Gating properties	Sensitivity for tetrodotoxin	[5355]
	Evoked by a step repolarization to −30 mV
	Maximum current at Vm=−30~−40 mV
	V_{1/2 activation}=−40 mV, rising time=5~6 ms
	V_{1/2 inactivation}=−62 mV (low Na+), −53 mV (high Na+), τ_decay=20~30 ms
Impact on excitability	Reopening Na_V when the membrane potential is repolarized to approximately −40 mV	[525455]
Impact on excitability	Shortens the refractory period between action potentials, high-frequency firing appears to be facilitated	[525455]
Ablation	Reduced spontaneous firing rates	[545556575859]
	Increased spike adaptation
	Cerebellar ataxia & Dysfunction of motor coordination
	Impairment of water maze and delayed eyeblink conditioning