KV1.4 & KV4 (A-type K+ channel) | ||
---|---|---|
Expression | Dendrite | [70] |
Gating properties | Sensitivity for high concentration of 4-AP about 1~10 mM (insensitive for DTX) | [607785] |
Fast-activating and inactivating channel | ||
Activated at subthreshold voltage around −60 mV | ||
V1/2 activation=−24.9 mV; V1/2 inactivation=−69.2 mV | ||
τdeactivation at −70 mV : 3~4 ms | ||
Impact on excitability | Acceleration of AP spike | |
Firing frequency firing pattern (rhythmic Na-Ca spike burst) | ||
Subthreshold variation of membrane properties | ||
Impact on plasticity and learning | Eyeblink conditioning derives dendritic excitability underlying downregulation of A-type K+ channel | [116117] |
KV1.1, KV1.2, KV1.6 (D-type K+ channel) | ||
---|---|---|
Expression | Dendrite | [70] |
Gating properties | Sensitivity for low concentration of 4-AP about 0.2~1 mM and DTX (2.8~25 nM) | [6077] |
Low-threshold and non-inactivating channel | ||
Activated at −40~−50 mV | ||
V1/2 activation=−20~−30 mV (KV1.2: −5~5 mV) | ||
τdeactivation=14~23 ms | ||
Impact on excitability | Spike frequency and adaption, dendritic excitability | [8283] |
Amplitude and duration of rebound depolarization | ||
Spontaneous bursts |
KV3.3 & KV3.4 | ||
---|---|---|
Expression | Soma and Dendrite | [6970] |
Gating properties | Sensitivity for TEA | [68] |
Rapid activating at suprathreshold and rapidly inactivating channel | ||
Peak amplitude at 30 mV from −70 mV | ||
V1/2 activation=−23.0 mV, τdecay=0.66 ms | ||
Impact on excitability | Repolarize the membrane potential and maintain repetitive firing | [6871] |
Dendritic burst firing through Ca2+- Na+ coupling | ||
Impact on plasticity and learning | Deletion of KV3.1/3.3 causes ataxic behavior | [73] |