Fig. 1. The reactive astrocytes have graded reactivity in STAB. (A) Experimental timeline for stab wound injury. (B) Representative confocal images for the GFAP expression (green; GFAP, blue; DAPI) in hippocampal CA1 region of ipsilateral or contralateral side of injured brain. core; <80 µm from injury site, penumbra; >80 µm from injury site. (C) The average intensity of GFAP immunoreactivity signal in CA1 region of ipsilateral or contralateral side of hippocampus. One-way ANOVA with Tukey's multiple comparison test (**p<0.01, ****p<0.0001) (n=6 for each group). (D) Cell density in stratum radiatum of ipsilateral or contralateral side of hippocampus. One-way ANOVA with Tukey's multiple comparison test (****p<0.0001, NS; non-significant, p>0.05) (n=6 for each group). (E) Sholl analysis for immunostained GFAP signals. Starting radius; 3 µm, Interval of each concentric circles; 1 µm. (F) The summarized intersect of immunostained GFAP signals crossing with the concentric circles. Unpaired two-tailed-t-test (**p<0.01) (n=13 for Contra; n=10 for Ipsi). (G) Ramification index of GFAP-stained astrocytic processes. Unpaired two-tailed-t-test (*p<0.05) (n=13 for Contra; n=10 for Ipsi).
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