Fig. 3. Tonic GABA current is high near the injury site. (A) Schematic illustration for tonic current recording in hippocampal CA1 pyramidal neurons by whole-cell patch clamp and experimental timeline for stab wound injury. (B) Representative traces of GABAA receptor-mediated current recorded from hippocampal CA1 pyramidal neurons in injured mice. Bic. indicates the adding of 50 µM bicuculline in the recording solution. (C) The amplitude of tonic current (n=6 for Contra; n=16 for Ipsi). (D) The amplitude of sIPSCs before bicuculline applications (n=6 for Contra; n=18 for Ipsi). (E) The frequency of sIPSCs before bicuculline applications. (n=6 for Contra; n=18 for Ipsi). Unpaired two-tailed-t-test (NS; non-significant, *p<0.05, p>0.05).
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