Fig. 5. Enhanced neuroinflammatory responses and increased mitochondrial fission protein in G2019S TG mouse lysates. Both young (4~6 months, n=3) and old (12~19 months, n=3) G2019S TG mice and non-TG littermates were used. (A) Brain lysates were subjected to Western blot using the indicated antibodies. Bands of interest were normalized by Coomassie Blue staining. Graphic analysis of each Western blot is shown. Student's t-test was used to separately compare the relative levels of CD68 (B), Drp1 (C), Tom20 (D) and Drp1/Tom20 (E) between non-TG littermate and G2019S TG in young and old mice. (F) The TNF-α level of brain lysates was measured by ELISA. The statistical analysis was performed by ANOVA with Bonferroni post-hoc test. *p<0.05, ***p<0.001, n.s., not significant.
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