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Fig. 1. Morin delays the onset of seizure activity in KA-treated mice. Mice received an oral administration of MH (20, 40, and 80 mg/kg per day) at 1 hour and 1 day prior to KA treatment and were then treated with an intra-hippocampal injection of KA to induce seizures. (A) Chemical structure of MH (Structure drawn with ACD/ChemSketch Freeware). (B) Schedule of experiments. This scheme provides an overview of the experimental schedules. (C) Treatment with MH significantly increased the latency of seizure onset 3 hours after KA treatment compared to treatment with KA alone (**p<0.01 vs. KA alone; one-way ANOVA and Tukey's post-hoc analysis; n=5, each experimental group). All values are expressed as the mean±SEM. (D) For 5 weeks following KA treatment, SRS occurrence was quantified using video recording. Differences between the two groups were analyzed with the Mann-Whitney U test (p=0.145 vs. KA alone; n=3, each experimental group).
Exp Neurobiol 2018;27:226~237
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