Fig. 4. Morin prevents the loss of hippocampal neurons in a KA-induced seizure model. Mice were treated with a unilateral intra-hippocampal injection of KA and killed 7 days later. Morin (80 mg/kg) was administrated orally 1 day prior to the KA injection, then continued once daily for 7 days. (A) Representative coronal sections of the hippocampus following NeuN immunostaining. Scale bar, 500 µm and 50 µm. (B) The histogram quantitatively shows the percentage of NeuN-positive neurons in the counting area of the hippocampal CA1 region compared with contralateral controls. ***p<0.001 vs. CON, ##p<0.01 vs. KA alone (one-way ANOVA and Tukey's post-hoc analysis; n=4, each experimental group). All values are expressed as the mean±SEM.
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