Fig. 5. Heatmap of olfactory transduction signaling (Kyoto Encyclopedia of Genes and Genomes [KEGG] pathway: mmu04740) and quantitative real-time reverse transcription-PCR (RT-PCR) of Omp and Stoml3 in the olfactory bulbs of control and EAE-affected mice. (A) Omp and Stoml3 were significantly downregulated. (B) Omp mRNA expression was significantly decreased at the paralytic stage (G.3; severe paraparesis, D23PI) and subsequently restored in the recovery stage (R.1; recovery with floppy tail, D83PI). (C) The expression level of Stoml3 mRNA was significantly decreased at the paralytic and recovery stages following immunization. PI, post-immunization. Data are presented as means±SEM. **p<0.01, vs. control group.
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