Fig. 4. Enhancement of peripheral phenotype by administration of LV-miR-381. LV-miR-381 (n = 10) or LV-mock (n = 6) were intraneurally administered to six-day-old C22 mice pups (p6). (A) Rotarod test from 3 weeks of age showing that LV-miR-381 treated C22 mice exhibited significantly increased performance from 9 weeks. (B and C) Nerve conduction study showing increased motor nerve conduction velocity (MNCV) (B) and compound muscle action potential (CMAP) (C) in LV-miR381 administered C22 mice compared to LV-mock treated C22 mice at 10 weeks post administration. *p<0.05; **p<0.01.
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