Fig. 6. Alterations in angiogenesis-related factors and cytokines over time following bilateral common carotid artery occlusion (BCCAo). (A) Western blots of hippocampal vascular endothelial growth factor (VEGF, n=5), cyclooxygenase-2 (COX-2, n=4), transforming growth factor β (TGF-β, n=4), and hypoxia inducible factor-1α (Hif-1α, n=4). (B) Hippocampal VEGF levels by quantified results of western blots significantly increased at 4 and 8 weeks (*) after BCCAo, compared to controls. (C) Fluorescent immunohistochemistry of hippocampal VEGF. (D) Hippocampal Hif-1α significantly increased at 4 weeks and 8 weeks following BCCAo compared to controls (*). (E, F) Hippocampal COX-2 and TGF-β increased at 1 and 4 weeks following BCCAo (*), although expression returned to control levels by 8 weeks (#, ##). Scale bar, 100 µm.
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