Fig. 4. Measurement of electrical signals of the ORNs following odorants stimulation. (A) Illustration of an experimental protocol of odorant detection with ORN-coupled MEA. (B) Illustration for odorant detection and discrimination using field potential patterns in the MEA. (C) Measured field potential patterns upon increasing IBMP concentrations for detection of odorant concentrations. (D) Dose-response curves of field potentials depending on the concentration of IMBP at representative five positions of electrodes [(2,4), (4,4), (4,7), (5,2), (7,5)]. (E) Entire intensities of field potentials measured at every single electrode in repetitive IBMP stimulations (*<0.05, **<0.01, ***<0.001). (F) Field-potential patterns of repetitive odorant stimulation using IVA, citralva, and IBMP. (G) Entire intensities of field potentials measured at every single electrode for three odorants stimulations (*<0.05, **<0.01, ***<0.001). (H) PCA for odorants discrimination. Data were obtained from three separate animal culture experiments.
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