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Fig. 9. LY294002 aggravated the suppression of PI3K/AKT signaling pathway induced by MEHP. CGCs were pre-treated with 5 µM of LY294002, an inhibitor of PI-3K/AKT pathway, for 2 h followed by treatment with 250 MEHP for 24 h. The corresponding graphs the semi-quantitative measurement of PI3K (B), p-AKT (C), AKT (D), Bcl-2 (E), Bax (F), total caspase-3 (G) and cleaved caspase-3 (H). Each column represents the mean±SD. Mean expression in CGCs from each MEHP exposure group is shown as a fold-change compared to the mean expression in the control group, which was ascribed an arbitrary value of 1. With each time point, *p<0.05 vs control, #p<0.05 vs 250 µM MEHP exposure group (n=4).
Exp Neurobiol 2018;27:472~488
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