Fig. 1. Selected AGMs regulating neuroinflammation and neuron-glia interactions. Recombinant Netrin-1 inhibits Aβ production by interacting with APP and DCC receptors. Recombinant Sema4D inhibits microglial activation through microglial receptors PlexinB1 and CD72. UNC5B can inhibit inflammatory activation of microglia and astrocytes when bound to endothelial Netrin-1. Interaction between neuronal EphB1 and astrocyte EphrinB1 mediates neuroprotective activation of astrocytes. Aβ, amyloid beta; µG, microglia; AS, astrocyte.
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