Fig. 1. Basic synaptic transmission and E-LTP are unaffected in Rev-erbα KO mice on the subjective day. (A) Input-output relationships at the hippocampal Schaffer-collateral-CA1-pyramidal (SC-CA1) synapses showed no significant difference between the WT and Rev-erbα KO mice (WT, 7 slices from 4 mice; Rev-erbα KO, 7 slices from 4 mice; repeated-measures two-way ANOVA, effect of genotype, F(1,12)=0.7524; p=0.9996). (B) The paired-pulse ratios showed no significant difference between the WT and KO mice. (WT, 6 slices from 4 mice; Rev-erbα KO, 7 slices from 4 mice; repeated-measures two-way ANOVA, effect of genotype, F(1,11)=0.4297; p=0.1009). (C) Example traces from baseline and LTP at times indicated by (a) and (b): WT (black) and KO (red). TBS-induced E-LTP was comparable between the WT and KO mice. (WT, 7 slices from 4 mice; Rev-erbα KO, 6 slices from 4 mice; average fEPSP slopes for the last 5 min; WT, 142.7%±8.039%; Rev-erbα KO, 137.7%±9.783%; unpaired t test, p=0.6970).
© Exp Neurobiol
