Fig. 2. Delayed gait ignition in JNPL3 mice. (A~F) Open-field test to evaluate general locomotor activity in 12-month-old WT and JNPL3 mice under bright (A~C) and dim red light (D~F) conditions (WT, n=19; JNPL3, n=12). Latency to gait ignition (A and D), time spent in the central zone of open-field arena (B and E), and total traveled distance (C and F) in WT and JNPL3 mice. Two-tailed unpaired t test, *p<0.05, **p<0.01, ***p<0.001. (G~I) Open-field test in 21-month-old WT and JNPL3 mice under bright light condition (WT, n=7; JNPL3, n=9). Mann-Whitney test, **p<0.01. (J) Gait initiation failure in balance beam walk test (WT, n=13; JNPL3, n=15). Mann-Whitney test, ***p<0.001. (K) Open-field test in 7-month-old WT and rTg4510 mice under bright light condition (WT, n=12; rTg4510, n=12). Two-tailed unpaired t test, p>0.05.
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