Fig. 4. Immunohistochemistry for PHF tau in JNPL3 hindbrain. (A) Schematic of circuits associated with initiation of locomotion (Cbl, cerebellum; MLR, mesencephalic locomotor region; CnF, cuneiform nucleus; PPN, pedunculopontine nucleus; RF, reticular formation; BSN, brainstem nuclei; IRt, Intermediate reticular nucleus; LPGi, Lateral paragigantocellular nucleus; LRt, Lateral reticular nucleus). (B) Immunohistochemical analysis of PHF tau expression levels in brainstem regions of JNPL3 mice (WT, n=3; JNPL3, n=3; 4V, fourth ventricle). Yellow boxes indicate magnified regions (LPGi). Scale bars, 50 µm. (C) Quantified PHF tau-immunopositive fluorescence intensity. Two-tailed unpaired t test, *p<0.01.
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