Fig. 2. A summary of consequences of LRRK2-mediated Rab phosphorylations. Two upstream regulators related to phosphorylation, VPS35 and Rab29 were shown [
81117120]. Relationship between VPS35 and Rab29 is unknown yet. Among LRRK2 kinase substrates, Rab5 and Rab29 are putative substrates [
96]. Activation of LRRK2 by Rab29 translocalizes LRRK2, Rab8, and Rab10 to lysosomal membranes, resulting in stabilization of Rabs on membranes after their phosphorylation [
81].
