Fig. 2. Ultra-wide-field color FP, AF, histology with H&E staining, and OCT images at one month after intravitreal injection of MNU without vitrectomy. One month after injection, no significant changes were observed in the FP, AF, histology, and OCT images of rabbit eyes with either 0.05 mg (a~d) or 0.1 mg (e~h) of injected MNU. Focal geographic hyper-AF areas (red arrows) were observed in the cases of 0.2 mg (j), 0.3 mg (n), and 0.4 mg (r) MNU injections. More severe retinal atrophy as seen in the photograph with H&E staining and OCT was induced via the 0.2 mg (k, l) and 0.4 mg (s, t) MNU injections versus with the 0.3 mg MNU injection (o, p). The green line on infrared FP shows the plane where the OCT image was harvested. Each scale bar on H&E staining (c, g, k, o, and s), infrared FP (left side image of d, h, l, p, and t), and OCT (right side image of d, h, l, p, and t) represents 100 µm, 800 µm, and 400 µm, respectively.
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