Fig. 3. Ultra-wide-field color FP and AF, spectral-domain OCT, and H&E staining images at one month after intravitreal MNU injection with pars plana vitrectomy. At one month after injection, no significant changes were observed in the FP, AF, OCT and H&E staining images of the rabbit eyes that received sham (a~d) or 0.05 mg (e~h) or 0.1 mg (i~l) of MNU injections after vitrectomy. Localized geographic hyper-AF areas with linear hyper-AF borders (red arrows) were observed with the 0.3 mg (n) and 0.5 mg (r) MNU injections after vitrectomy. Additionally, degenerative changes to the retina in OCT were observed in 0.3 mg (p) and 0.5 mg (t) MNU injections after vitrectomy. Loss of the photoreceptor layer and disruption of the layers of the retina were observed via H&E staining at the degeneration region with OCT (o, s). The green line on infrared FP shows the plane where the OCT image was harvested. Each scale bar on H&E staining (c, g, k, o, and s), infrared FP (left side image of d, h, l, p, and t), and OCT (right side image of d, h, l, p, and t) represents 100 µm, 800 µm, and 400 µm, respectively.
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