Fig. 6. Comparison of MNU injection between non-vitrectomy and vitrectomy group. Both without pars plana vitrectomy (PPV) group and with PPV group, 4 rabbits per each MNU dose were used. The exception was found with 0.2 mg MNU injection, 7 rabbits for each PPV group and non-PPV group, respectively. (a) Without vitrectomy group, 0.2 mg MNU induced significantly more retinal thinning than 0.1 mg (***p<0.001) but there was no difference between 0.2 mg and 0.3 mg injection (not significant (n.s): p>0.05). With vitrectomy group, 0.2 mg MNU induced significantly different retinal thinning with all other doses (0.1 mg, 0.3 mg, and 0.5 mg). (b) Comparison of 0.2 mg MNU injection between non-PPV group and PPV group. In non-PPV group (n=7), significantly more retinal thinning was induced than that in PPV group (**p<0.01). The standard deviation (S.D.) was smaller in vitrectomy group than non-vitrectomy group. (c) From the data of A, curve fitting was performed, and sigmoidal curve fit provides the best R2 value (R2= 0.99) in vitrectomy group. Mean and S.D. was shown in each figure. Student-t test was performed for statistical analysis.
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