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Fig. 2. JAK-STAT signaling as an anti-inflammatory target. JAK-STAT signaling mediates the brain inflammation induced by LPS, IFN-γ, ganglioside and thrombin. Curcumin activates SH2-containing phosphatase 2 (SHP2), while rosiglitazone and 15d-PGJ2 increase the expressions of SOCS1 and SOCS3. SHP2 and the SOCS proteins are typical negative feedback molecules of the JAK-STAT pathway.
Exp Neurobiol -0001;24:95~102
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