Fig. 4. MKP-1 as an anti-inflammatory target. The expression of MCP-1, a crucial molecule in initiating inflammatory responses, is regulated by JNK. MKP-1 dephosphorylates and inactivates JNK, suppressing MCP-1 expression. 15d-PGJ2, ETYA, and 22(R)-hydroxycholesterol (22R-HC) induce MKP-1 expression via HuR-dependent post-transcriptional regulation.
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