Fig. 2. Dexmedetomidine attenuated the mechanical and thermal hyperalgesia caused by CCI in rats. (A) Dexmedetomidine attenuated mechanical hyperalgesia. The mechanical paw withdrawal threshold in the CCI+DEX group was significantly higher than that in the CCI+NS group from day 8 to day 10 following CCI (n=8, mean±SEM, ***p<0.001, ANOVA). (B) Dexmedetomidine attenuated thermal hyperalgesia. The thermal paw withdrawal latency in the CCI+DEX group was significantly higher than that in the CCI+NS group from day 8 to day 10 following CCI (n=8, mean±SEM, ***p<0.001, ANOVA). CCI, chronic constriction injury; NS, normal saline; DEX, dexmedetomidine.
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