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Fig. 7. C3a administration alone increases the expression of Caspase3, ICAM-1 and pERK ½ in bEnd.3 cells but not C3aR following OGD. A~H) C3a treatment significant enhanced the Caspase3, ICAM-1 and pERK level with OGD but not C3aR expression compared with OGD group. C3aRA treatment significantly reduced the level of these markers including C3aR with and without C3a. Color intensity was measured by Image J. The results represent the means±SEM of fold changes (n=5). *p<0.01, **p<0.001, ***p<0.0001. Cont, Control group; Cont+C3a, Cont+C3a+C3aRA; OGD, OGD, OGD+C3a, and, OGD+C3a+C3aRA.
Exp Neurobiol 2019;28:216~228
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