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Fig. 1. Time-dependent progression of cerebral infarct after ischemic stroke. (A) Representative TTC-stained brain sections and the corresponding MR images from rats at the indicated post-stroke time points. (B) H&E staining of TTC-stained brain sections. Cell body shrinkage and perineuronal vacuolization were detected in the ischemic core from the early time points. Note the cell body shrinkage with darkly stained pyknotic nuclei in the striatum at 0 h (arrows). (C) Immunohistochemical analysis of NeuN-positive neurons. Neuronal degeneration initiated at 0 h (just after the reperfusion) in the striatum and 2 h in the cortex. The boxed areas in the full-size brain images are magnified in the representative image. Scale bar, 20 µm.
Exp Neurobiol 2018;27:287~298
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