Fig. 1. Degeneration of DA neurons in the substantia nigra in LRRK2 R1441G mutant mice. DA neurons were detected by TH-specific antibody. LRRK2 R1441G mutation decreased TH positive DA neurons at 10~11 months (Normal: R1441G=8:8), 15~16 months (Normal: R1441G=7:7), and 20~24 months (Normal: R1441G=7:7) of age (*<0.05). Data are expressed as the mean±SEM. Scale bars indicate 50 μm.
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