Fig. 2. The effect of VPA on the histone acetylation (A) and protein expression level of HDACs (B). Expression levels of histone 3 and β-actin were considered as loading controls and used for normalization. VPA significantly increased acetylation of histone and LRRK2 R1441G mutation increased the expression of HDAC1, HDAC2, and HDAC3 proteins (*p<0.05). Data are expressed as the mean±SEM of four independent experiments.
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