Fig. 5. The effect of VPA on the motor (A, B) or non-motor (C) behaviors in LRRK2 R1441G mutant mice. VPA significantly increased latency to fall and significantly decreased both the number of rearing and wall rearing in LRRK2 R1441G mice compared to normal control mice. VPA significantly decreased the time spent in center in open field test, and time spent in open arms in elevated plus maze, compared to vehicle group (*p<0.05). Data are expressed as the mean±SEM of four independent experiments.
© Exp Neurobiol
