Fig. 1. NMDA-induced spasms were increased in rat offspring following prenatal exposure to betamethasone. Frequency (per hour) (A) and latency (second) (B) to the onset of flexion spasms induced by intraperitoneal NMDA administration were measured in control and betamethasone-treated P15 animals. (A) Frequency of spasms was increased in the offspring prenatally exposed to betamethasone, compared to that in control. (B) Latency to the onset of spasms was decreased in betamethasone-treated P15 animals compared to the control. Statistical significance was assessed by one-way ANOVA. Error bars denote SEM (***p<0.001, n=6 in each).
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