Fig. 5. Differential modulation of the neuronal excitability under EGTA or BAPTA condition by Zn2+ in the presence of nifedipine, dantrolene, apamin. Left, current-injected voltage raw traces by a depolarizing pulse (100 pA current injection for 1 s) under BAPTA condtion. Middle, effect of buffer chelators on the frequency of evoked action potentials. Right, effect of buffer chelators on the frequency of evoked action potentials by Zn2+. (A) In the presence of nifedipine. Middle, EGTA, 0.73±0.05 Hz, n=8; BAPTA, 0.21±0.09 Hz, n=5; ***p<0.001, unpaired t-test. Right, EGTA, 0.98±0.19 Hz, n=8; BAPTA, 0.17±0.17 Hz, n=3; *p<0.05, unpaired t -test. (B) In the presence of dantrolene. Middle, EGTA, 1.06±0.12 Hz, n=4; BAPTA, 0.55±0.12 Hz, n=8; *p<0.05, unpaired t-test. Right, EGTA, 1.03±0.11 Hz, n=4; BAPTA, 0.48±0.14 Hz, n=7; *p<0.05, unpaired t-test. (C) In the presence of apamin. Middle, EGTA, 1.97±0.29 Hz, n=4; BAPTA, 0.79±0.13 Hz, n=4; **p<0.01, unpaired t-test. Right, EGTA, 0.98±0.13 Hz, n=4; BAPTA, 0.64±0.08 Hz, n=4; *p<0.05, unpaired t-test.
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